Polyphenol-rich foods could have a pivotal function in the prevention of oxidative\nstress-based pathologies and antibacterial action. The purpose of this study was to investigate\nthe in vitro antimicrobial activity, as well as the in vitro and In Vivo antioxidant capacities of wild\nPrunus spinosa L. fruit (PSF) from the southeast regions of Italy. The total phenolic content (TPC)\nwas quantified, and the single polyphenols were analyzed by HPLC-DAD, showing high rutin and\n4-hydroxybenzoic acid levels, followed by gallic and trans-sinapic acids. PSF extract demonstrated\nantimicrobial activity against some potentially pathogenic Gram-negative and Gram-positive bacteria.\nBesides, we investigated the cellular antioxidant activity (CAA) and the hemolysis inhibition of\nPSF extract on human erythrocytes, evidencing both a good antioxidant power and a marked\nhemolysis inhibition. Furthermore, an In Vivo experiment with oxidative stress-induced rats treated\nwith a high-fat diet (HFD) and a low dose of streptozotocin (STZ) demonstrated that PSF has a\ndose-dependent antioxidant capacity both in liver and in brain. In conclusion, the wild Italian Prunus\nspinosa L. fruit could be considered a potentially useful material for both nutraceutical and food\nindustries because of its antioxidant and antimicrobial effects.
Loading....